There is a marriage record for a second husband (Lucien Isaacs) but she was buried under her first spouse's name.  She is listed as Mrs. Isaacs on her son Leo's internment record shown on Find a Grave.
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13 JUN 1900 Van Buren Township (east half), Brown, Indiana
District 29 Sheet 6B 121/121
Henry J Brand Head M 27 Indiana
Louisa J Brand Wife F 27 Indiana
Nellie A Brand Daughter F 4 Indiana
Earnest Brand Son M 1 Indiana
27 APR 1910 Van Buren, Brown, Indiana
ED 33, Sheet 6A
Henry J Brand Head M 36 Indiana
Louie J Brand Wife F 31 Ohio
Nellie A Brand Daughter F 14 Indiana
Ernest D Brand Son M 10 Indiana
Opal B Brand Daughter F 7 Indiana
Eben S Brand Son M 5 Indiana
Leo Brand Son M 2 Indiana
8 JAN 1920 Van Buren, Brown, Indiana
ED 28 Sheet 2B 47/47
Henry J Brand Head M 48 Indiana
Lewie O Brand Wife F 41 Ohio
Ople Brand Daughter F 16 Indiana
Ebem Brand Son M 14 Indiana
Leo T Brand Son M 12 Indiana
Burnadine W Brand Daughter F 0 Indiana